Cognex

DRUG DESCRIPTION

Cognex® (tacrine hydrochloride) is a reversible cholinesterase inhibitor, known chemically as 1,2,3,4-tetrahydro-9-acridinamine monohydrochloride monohydrate. Tacrine hydrochloride is commonly referred to in the clinical and pharmacological literature as THA. It has an empirical formula of C13H14N2•HCl•H2O and a molecular weight of 252.74.

The molecular formula of tacrine hydrochloride is:

Cognex® (Tacrine Hydrochloride) Structural Formula Illustration

Tacrine hydrochloride is a white solid and is freely soluble in distilled water, 0.1N hydrochloric acid, acetate buffer (pH 4.0), phosphate buffer (pH 7.0 to 7.4), methanol, dimethylsulfoxide (DMSO), ethanol, and propylene glycol. The compound is sparingly soluble in linoleic acid and PEG 400.

Each capsule of Cognex® contains tacrine as the hydrochloride. Inactive ingredients are hydrous lactose, magnesium stearate, and microcrystalline cellulose. The hard gelatin capsules contain gelatin, NF; silicon dioxide, NF; sodium lauryl sulfate, NF; and the following dyes: 10 mg: D&C Yellow #10, FD&C Green #3, titanium dioxide; 20 mg: D&C Yellow #10, FD&C Blue #1, titanium dioxide; 30 mg: D&C Yellow #10, FD&C Blue #1, FD&C Red #40, titanium dioxide; 40 mg: D&C Yellow #10, FD&C Blue #1, FD&C Red #40, D&C Red #28, titanium dioxide.

Each 10-, 20-, 30-, and 40-mg Cognex® (tacrine) capsule for oral administration contains 12.75, 25.50, 38.25, and 51.00 mg of tacrine HCl, respectively.

What are the possible side effects of tacrine (Cognex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • confusion, hallucinations;
  • extreme or sudden changes in behavior;
  • seizure (convulsions);
  • pain or burning when you urinate; or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or...

Read All Potential Side Effects and See Pictures of Cognex »

What are the precautions when taking tacrine (Cognex)?

Before taking tacrine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of liver problems caused by tacrine.

Before using this drug, tell your doctor your medical history, including: breathing problems (e.g., asthma, chronic obstructive pulmonary disease-COPD), heart problems (e.g., abnormal heart rhythm), liver disease, seizures, stomach/intestinal disease (e.g., ulcers, bleeding), trouble urinating.

This drug may cause loss...

Read All Potential Precautions of Cognex »


Cognex Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, diarrhea, stomach upset, loss of appetite, muscle aches, shaking (tremors), and loss of balance may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: weight loss, slow heartbeat, trouble urinating, change in amount of urine.

Tell your doctor immediately if any of these rare but very serious side effects occur: severe stomach/abdominal pain, dark urine, yellowing of eyes/skin, black stools, vomit that looks like coffee grounds, seizures.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking tacrine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of liver problems caused by tacrine.

Before using this drug, tell your doctor your medical history, including: breathing problems (e.g., asthma, chronic obstructive pulmonary disease-COPD), heart problems (e.g., abnormal heart rhythm), liver disease, seizures, stomach/intestinal disease (e.g., ulcers, bleeding), trouble urinating.

This drug may cause loss of coordination. Do not drive, use machinery, or do any activity that requires good coordination until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist that you are using this medication.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Cognex Patient Information Including Side Effects

Brand Names: Cognex

Generic Name: tacrine (Pronunciation: TAK rin)

  • What is tacrine (Cognex)?
  • What are the possible side effects of tacrine (Cognex)?
  • What is the most important information I should know about tacrine (Cognex)?
  • What should I discuss with my healthcare provider before taking tacrine (Cognex)?
  • How should I take tacrine (Cognex)?
  • What happens if I miss a dose (Cognex)?
  • What happens if I overdose (Cognex)?
  • What should I avoid while taking tacrine (Cognex)?
  • What other drugs will affect tacrine (Cognex)?
  • Where can I get more information?

What is tacrine (Cognex)?

Tacrine improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah see til KO leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning.

Tacrine is used to treat mild to moderate dementia caused by Alzheimer's disease.

Tacrine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of tacrine (Cognex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • confusion, hallucinations;
  • extreme or sudden changes in behavior;
  • seizure (convulsions);
  • pain or burning when you urinate; or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects of tacrine include:

  • mild nausea, vomiting, diarrhea, upset stomach;
  • weight loss;
  • urinating more than usual;
  • agitation, depressed mood;
  • skin rash, increased sweating;
  • fever or chills, runny nose, cough;
  • dizziness, drowsiness, tired feeling;
  • joint or muscle pain; or
  • weakness, lack of coordination.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about tacrine (Cognex)?

Before taking tacrine, tell your doctor if you have heart disease or a heart rhythm disorder such as "sick sinus syndrome" (slow heartbeats), an enlarged prostate, urination problems, asthma, obstructive pulmonary disease, or a seizure disorder such as epilepsy.

Tacrine is most effective when taken between meals on an empty stomach, but you may take it with food if it upsets your stomach.

It is important to use tacrine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Do not change your tacrine dose without your doctor's advice. Taking this medication improperly can lead to serious behavioral side effects or a worsening of Alzheimer's symptoms.

Call your doctor at once if you have serious side effects such as confusion, hallucinations, extreme or sudden changes in behavior, seizure (convulsions), pain or burning when you urinate, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Do not stop taking this medication without first talking to your doctor. If you stop taking tacrine suddenly, your condition may become worse.

Tacrine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

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