Aristocort® Forte (triamcinolone diacetate injectable suspension) is a sterile suspension of 40 mg/mL of triamcinolone diacetate (micronized) suspended in a vehicle consisting of:

Polysorbate 80 0.20%
Polyethylene Glycol 3%
Sodium Chloride 0.85%
Benzyl Alcohol 0.90%
Water for Injection q.s. 100%

Hydrochloric acid and/or sodium hydroxide may be used during manufacture to adjust pH of suspension to approximately 6.

Triamcinolone diacetate is practically insoluble in water; soluble in chloroform; sparingly soluble in alcohol and in methanol; and slightly soluble in ether. This preparation is suitable for parenteral administration through a 23-gauge needle (or larger), but NOT suitable for intravenous use. It may be administered by the intramuscular, intra-articular, or intrasynovial routes, depending upon the situation.

Irreversible clumping occurs when this product is frozen.

Chemically triamcinolone diacetate is 9-fluoro-11?,16&?;,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,21-diacetate.

The molecular weight is 478.51. Its structural formula is:

Aristocort® Forte (triamcinolone diacetate injectable suspension) 
  (Triamcinolone Diacetate) Structural Formula Illustration

Triamcinolone diacetate occurs as a white to off-white, microcrystalline powder.

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