Trecator

DRUG DESCRIPTION

Trecator® (ethionamide tablets, USP) is used in the treatment of tuberculosis. The chemical name for ethionamide is 2-ethylthioisonicotinamide with the following structural formula:

Trecator® (ethionamide) structural formula illustration

Ethionamide is a yellow crystalline, nonhygroscopic compound with a faint to moderate sulfide odor and a melting point of 162°C. It is practically insoluble in water and ether, but soluble in methanol and ethanol. It has a partition coefficient (octanol/water) Log P value of 0.3699. Trecator (ethionamide tablets) tablets contain 250 mg of ethionamide. The inactive ingredients present are croscarmellose sodium, FD&C Yellow #6, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, talc, and titanium dioxide.

What are the possible side effects of ethionamide (Trecator-SC)?

If you experience any of the following serious side effects, stop taking ethionamide and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • yellow skin or eyes;
  • dark urine;
  • numbness or tingling in your hands or feet;
  • seizures;
  • blurred or double vision; or
  • confusion or abnormal behavior.

Other, less serious side effects may be more likely to...

Read All Potential Side Effects and See Pictures of Trecator »

What are the precautions when taking ethionamide tablets (Trecator)?

Before taking ethionamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, underactive thyroid (hypothyroidism), eye problems (such as optic neuritis, cataracts, diabetic retinopathy).

Alcohol may increase the risk of liver disease or mental/mood changes. Avoid alcoholic beverages while using this medication.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal...

Read All Potential Precautions of Trecator »


Trecator Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, diarrhea, abdominal/stomach pain, increased saliva, strange metallic taste in the mouth, loss of appetite, or sores in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication may develop serious side effects, but with frequent visits to your doctor, this risk can be minimized.

Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual hunger, unusual sweating, shakiness, persistent nausea/vomiting, unusual tiredness/weakness, yellowing eyes/skin, dark urine, joint pain/swelling, slow heartbeat, mental/mood changes (such as nervousness, restlessness, depression).

Tell your doctor immediately if any of these rare but serious side effects occur: vision changes (such as blurred/decreased/double vision, color blindness), eye pain, numbness/tingling of arms/legs.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking ethionamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, underactive thyroid (hypothyroidism), eye problems (such as optic neuritis, cataracts, diabetic retinopathy).

Alcohol may increase the risk of liver disease or mental/mood changes. Avoid alcoholic beverages while using this medication.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If you have diabetes, this product may make it harder to control your blood sugar levels (cause low blood sugar). Check your blood sugar levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of low blood sugar, such as shakiness, unusual hunger, or unusual sweating. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.


Trecator Patient Information Including Side Effects

Brand Names: Trecator-SC

Generic Name: ethionamide (Pronunciation: e thye on AM ide)

  • What is ethionamide (Trecator)?
  • What are the possible side effects of ethionamide (Trecator)?
  • What is the most important information I should know about ethionamide (Trecator)?
  • Who should not take ethionamide (Trecator)?
  • How should I take ethionamide (Trecator)?
  • What happens if I miss a dose (Trecator)?
  • What happens if I overdose (Trecator)?
  • What should I avoid while taking ethionamide (Trecator)?
  • What other drugs will affect ethionamide (Trecator)?
  • Where can I get more information?

What is ethionamide (Trecator)?

Ethionamide is an antibiotic. It prevents the growth of bacteria in your body.

Ethionamide is used to treat tuberculosis (TB).

Ethionamide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of ethionamide (Trecator)?

If you experience any of the following serious side effects, stop taking ethionamide and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • yellow skin or eyes;
  • dark urine;
  • numbness or tingling in your hands or feet;
  • seizures;
  • blurred or double vision; or
  • confusion or abnormal behavior.

Other, less serious side effects may be more likely to occur. Continue to take ethionamide and talk to your doctor if you experience

  • nausea, vomiting, or loss of appetite;
  • a metallic taste in your mouth;
  • excessive salivation;
  • diarrhea;
  • unusual fatigue or weakness;
  • headache;
  • mild dizziness;
  • tremors (shaking); or
  • a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ethionamide (Trecator)?

Take all of the ethionamide that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Ethionamide may cause stomach upset, a loss of appetite, a metallic taste in your mouth, or excessive salivation (mouth watering). Notify your doctor if these side effects are persistent or severe.

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