Xenazine

DRUG DESCRIPTION

Xenazine® (tetrabenazine) is a monoamine depletor for oral administration. The molecular weight of tetrabenazine is 317.43, the pKa is 6.51. Tetrabenazine is a hexahydro-dimethoxybenzoquinolizine derivative and has the following chemical name: cis rac –1,3,4,6,7,11bhexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one.

The empirical formula C19H27NO3 is represented by the following structural formula:

Xenazine® (tetrabenazine) Structural Formula Illustration

Tetrabenazine is a white to slightly yellow crystalline powder that is sparingly soluble in water and soluble in ethanol.

Each XENAZINE® (tetrabenazine) Tablet contains either 12.5 or 25 mg of tetrabenazine as the active ingredient. XENAZINE® (tetrabenazine) Tablets contain tetrabenazine as the active ingredient and the following inactive ingredients: lactose, maize starch, talc, and magnesium stearate. The 25-mg strength tablet also contains yellow iron oxide as an inactive ingredient. XENAZINE® (tetrabenazine) is supplied as a yellowish-buff scored tablet containing 25-mg of tetrabenazine, or as a white non-scored tablet containing 12.5-mg of tetrabenazine.

What are the possible side effects of tetrabenazine (Xenazine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tetrabenazine and call your doctor at once if you have a serious side effect such as:

  • mood or behavior changes;
  • extreme drowsiness, feeling like you might pass out;
  • feeling restless, agitated, or hyperactive (mentally or physically);
  • thoughts about suicide or hurting yourself.
  • restless muscle movements in...

Read All Potential Side Effects and See Pictures of Xenazine »


Xenazine Patient Information Including Side Effects

Brand Names: Xenazine

Generic Name: tetrabenazine (Pronunciation: TET ra BEN a zeen)

  • What is tetrabenazine (Xenazine)?
  • What are the possible side effects of tetrabenazine (Xenazine)?
  • What is the most important information I should know about tetrabenazine (Xenazine)?
  • What should I discuss with my health care provider before taking tetrabenazine (Xenazine)?
  • How should I take tetrabenazine (Xenazine)?
  • What happens if I miss a dose (Xenazine)?
  • What happens if I overdose (Xenazine)?
  • What should I avoid while taking tetrabenazine (Xenazine)?
  • What other drugs will affect tetrabenazine (Xenazine)?
  • Where can I get more information?

What is tetrabenazine (Xenazine)?

Tetrabenazine reduces the amount of certain chemicals in the body that are overly active in people with Huntington's disease.

Tetrabenazine is used to treat Huntington's chorea (uncontrolled muscle movements).

Tetrabenazine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of tetrabenazine (Xenazine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tetrabenazine and call your doctor at once if you have a serious side effect such as:

  • mood or behavior changes;
  • extreme drowsiness, feeling like you might pass out;
  • feeling restless, agitated, or hyperactive (mentally or physically);
  • thoughts about suicide or hurting yourself.
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • trouble swallowing;
  • tremor (uncontrolled shaking);
  • dizziness, fainting, fast or pounding heartbeat; or
  • high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing.

Less serious side effects may include:

  • sleep problems (insomnia);
  • mild drowsiness, tired feeling;
  • nausea; or
  • breast swelling or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about tetrabenazine (Xenazine)?

You should not use this medication if you are allergic to tetrabenazine, or if you have severe or untreated depression, suicidal thoughts, liver disease, or past or present breast cancer.

Do not use tetrabenazine if you have taken reserpine within the past 20 days, or if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) within the past 14 days.

Before you take tetrabenazine, tell your doctor if you have heart disease, a personal or family history of "Long QT syndrome," or a history of depression or suicidal thoughts or actions.

Tetrabenazine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

You may feel depressed or have thoughts about suicide when you first start taking this medication. Your doctor will need to check you at regular visits during treatment.

Stop taking tetrabenazine and call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, confusion, trouble swallowing, uncontrolled muscle movements, extreme drowsiness, or if you feel restless, agitated, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

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