MYOZYME® (alglucosidase alfa) consists of the human enzyme acid ?-glucosidase (GAA), encoded by the most predominant of nine observed haplotypes of this gene. MYOZYME (alglucosidase alfa) is produced by recombinant DNA technology in a Chinese hamster ovary cell line. Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of ?-1,4- and ?-1,6-glycosidic linkages of lysosomal glycogen.

LUMIZYME (alglucosidase alfa) consists of the human enzyme acid ?-glucosidase (GAA), encoded by the most predominant of nine observed haplotypes of this gene. LUMIZYME (alglucosidase alfa) is produced by recombinant DNA technology in a Chinese hamster ovary cell line. The LUMIZYME (alglucosidase alfa) manufacturing process differs from that for MYOZYME, resulting in differences in some product attributes. Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of ?-1,4- and ?-1,6 glycosidic linkages of lysosomal glycogen.