Rescula

(Generic versions may still be available.)

DRUG DESCRIPTION

Unoprostone Isopropyl is a docosanoid, a structural analogue of an inactive biosynthetic cyclic derivative of arachidonic acid, 13, 14-dihydro-15-keto-prostaglandin F2a. Its chemical name is isopropyl (+)-(Z)-7-[(1R, 2R, 3R, 5S)-3,5-dihydroxy-2-(3-oxodecyl) cyclopentyl] -5-heptenoate. Its molecular formula is C25H44O5.

Unoprostone isopropyl is a clear, colorless viscous liquid that is very soluble in acetonitrile, ethanol, ethyl acetate, isopropanol, dioxane, ether, and hexane. It is practically insoluble in water. RESCULA? (unoprostone isopropyl ophthalmic solution) 0.15% is supplied as a sterile, isotonic, buffered aqueous solution of unoprostone isopropyl with a pH of 5.0 6.5 and an osmolality of 235 - 300 mOsmol/kg.

Each mL of Rescula contains 1.5 mg of unoprostone isopropyl. Benzalkonium chloride 0.015% is added as a preservative. Inactive ingredients are: mannitol, polysorbate 80, edetate disodium, sodium hydroxide or hydrochloric acid (to adjust pH), and water for injection.

What are the possible side effects of unoprostone ophthalmic (Rescula)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using unoprostone ophthalmic and call your doctor at once if you have any of these serious side effects:

  • redness, swelling, itching, or pain in or around your eye;
  • oozing or discharge from your eye;
  • increased sensitivity to light; or
  • vision changes.

Less serious side effects may include:

    ...

Read All Potential Side Effects and See Pictures of Rescula


Rescula Patient Information Including Side Effects

Brand Names: Rescula

Generic Name: unoprostone ophthalmic (Pronunciation: uh no PROSS tone)

  • What is unoprostone ophthalmic (Rescula)?
  • What are the possible side effects of unoprostone ophthalmic (Rescula)?
  • What is the most important information I should know about unoprostone ophthalmic (Rescula)?
  • What should I discuss with my health care provider before using unoprostone ophthalmic (Rescula)?
  • How should I use unoprostone ophthalmic (Rescula)?
  • What happens if I miss a dose (Rescula)?
  • What happens if I overdose (Rescula)?
  • What should I avoid while using unoprostone ophthalmic (Rescula)?
  • What other drugs will affect unoprostone ophthalmic (Rescula)?
  • Where can I get more information?

What is unoprostone ophthalmic (Rescula)?

Unoprostone ophthalmic reduces pressure in the eye by increasing the amount of fluid that drains from the eye.

Unoprostone ophthalmic is used to treat certain types of glaucoma and other causes of high pressure inside the eye.

Unoprostone ophthalmic may also be used for other purposes not listed in this medication guide.

What are the possible side effects of unoprostone ophthalmic (Rescula)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using unoprostone ophthalmic and call your doctor at once if you have any of these serious side effects:

  • redness, swelling, itching, or pain in or around your eye;
  • oozing or discharge from your eye;
  • increased sensitivity to light; or
  • vision changes.

Less serious side effects may include:

  • cold or flu symptoms such as fever, chills, runny nose, sore throat, cough, diarrhea, and body aches;
  • headache, dizziness;
  • mild eye discomfort;
  • blurred vision;
  • feeling like something is in your eye;
  • dry or watery eyes; or
  • stinging or burning of the eyes after using the drops.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What is the most important information I should know about unoprostone ophthalmic (Rescula)?

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using unoprostone before putting your contact lenses in.

Unoprostone ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

After using this medication, wait at least 5 minutes before using any other eye drops that your doctor has prescribed.

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