Virazole

DRUG DESCRIPTION

VIRAZOLE is a brand name for ribavirin, a synthetic nucleoside with antiviral activity. VIRAZOLE (ribavirin) for inhalation solution is a sterile, lyophilized powder to be reconstituted for aerosol administration. Each 100 mL glass vial contains 6 grams of ribavirin, and when reconstituted to the recommended volume of 300 mL with sterile water for injection or sterile water for inhalation (no preservatives added), will contain 20 mg of ribavirin per mL, pH approximately 5.5. Aerosolization is to be carried out in a Small Particle Aerosol Generator (SPAG-2) nebulizer only.

Ribavirin is 1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-cart)oxamide: with the following structural formula:

VIRAZOLE (Ribavirin) structural formula illustration

Ribavirin is a stable, white crystalline compound with a maximum solubility in water of 142 mg/mLat25C and with only a slight solubility in ethanol. The empirical formula is C8Hl2N405 and the molecular weight is 244.21.

What are the precautions when taking ribavirin (Virazole)?

Before your child receives ribavirin for inhalation, tell the doctor or pharmacist if your child is allergic to it; or if your child has any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell the doctor or pharmacist your child's medical history, especially of: breathing disorders (e.g., asthma).

This product is not usually used in adults. Therefore, it is unlikely to be used during pregnancy or breast-feeding. Consult your doctor if you have any questions about this product. (See also health care worker information in How to Use...

Read All Potential Precautions of Virazole


Virazole Consumer (continued)

SIDE EFFECTS: Chest soreness may occur. Redness/irritation of the eye or eyelid may also occur. If any of these effects persist or worsen, tell the doctor or pharmacist promptly.

Remember that the doctor has prescribed this medication because he or she has judged that the benefit to your child is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell the doctor immediately if any of these unlikely but serious side effects occur: pale/bluish skin around the mouth/lips/fingernails, worsening of breathing trouble, slow/fast/irregular heartbeat.

Tell the doctor immediately if any of these rare but very serious side effects occur: fainting, seizure.

This medication may infrequently cause anemia, usually within 1 to 2 weeks after treatment is started. Tell the doctor immediately if you notice any symptoms of anemia such as unusual tiredness or fast/pounding heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact the doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before your child receives ribavirin for inhalation, tell the doctor or pharmacist if your child is allergic to it; or if your child has any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell the doctor or pharmacist your child's medical history, especially of: breathing disorders (e.g., asthma).

This product is not usually used in adults. Therefore, it is unlikely to be used during pregnancy or breast-feeding. Consult your doctor if you have any questions about this product. (See also health care worker information in How to Use section.)



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