Visudyne

DRUG DESCRIPTION

VISUDYNE® (verteporfin for injection) is a light activated drug used in photodynamic therapy. The finished drug product is a lyophilized dark green cake. Verteporfin is a 1:1 mixture of two regioisomers (I and II), represented by the following structures:

Visudyne (verteporfin) structural formula illustration

The chemical names for the verteporfin regioisomers are:

9-methyl (I) and 13-methyl (II) trans-(± )-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H, 25H-benzo[b]porphine-9,13-dipropanoate

The molecular formula is C41H42N4O8 with a molecular weight of approximately 718.8. Each mL of reconstituted VISUDYNE contains:

ACTIVE: Verteporfin, 2 mg

INACTIVES: Lactose, egg phosphatidylglycerol, dimyristoyl phosphatidylcholine, ascorbyl palmitate and butylated hydroxytoluene

What are the possible side effects of verteporfin (Visudyne)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; sweating; dizziness; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • severe decrease in vision;
  • sudden and severe pain;
  • severe redness or other discoloration of your eyes;
  • eye pain or seeing halos around lights;
  • feeling like you might pass out;
  • chest pain; or
  • warmth or...

Read All Potential Side Effects and See Pictures of Visudyne »

What are the precautions when taking verteporfin inj (Visudyne)?

Before using this medication, tell your doctor or pharmacist if you are allergic to verteporfin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain metabolic disorder (porphyria).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.

This medication will make you more sensitive to the sun and to bright indoor lights. Avoid sun exposure, halogen lights, high-powered indoor lighting used in operating rooms/dental offices,...

Read All Potential Precautions of Visudyne »


Visudyne Consumer (continued)

SIDE EFFECTS: Injection site reactions (e.g., pain, redness, irritation, swelling), headache, tiredness, or blurred vision may occur. If any of these effects persist or worsen, tell your doctor promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: chest pain, fainting, sweating.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), flushing, severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to verteporfin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain metabolic disorder (porphyria).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.

This medication will make you more sensitive to the sun and to bright indoor lights. Avoid sun exposure, halogen lights, high-powered indoor lighting used in operating rooms/dental offices, tanning booths, and sunlamps for at least 5 days after receiving this medication. Wear protective clothing and dark sunglasses when outdoors. Sunscreens will not provide protection.

Before having surgery, tell your doctor or dentist that you are using this medication. It is recommended that you avoid surgery/dental procedures for at least 5 days after receiving a dose of this medication.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.


Visudyne Patient Information Including Side Effects

Brand Names: Visudyne

Generic Name: verteporfin (Pronunciation: VER te PORE fin)

  • What is verteporfin (Visudyne)?
  • What are the possible side effects of verteporfin (Visudyne)?
  • What is the most important information I should know about verteporfin (Visudyne)?
  • What should I discuss with my health care provider before I receive verteporfin (Visudyne)?
  • How is verteporfin given (Visudyne)?
  • What happens if I miss a dose (Visudyne)?
  • What happens if I overdose (Visudyne)?
  • What should I avoid after I receive verteporfin (Visudyne)?
  • What other drugs will affect verteporfin (Visudyne)?
  • Where can I get more information?

What is verteporfin (Visudyne)?

Verteporfin works by enhancing the eye's sensitivity to light. Verteporfin affects abnormal blood vessels in the eye.

Verteporfin is used together with "photodynamic" laser light therapy to treat blood vessel disorders in the eye caused by macular degeneration and other eye diseases.

Verteporfin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of verteporfin (Visudyne)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; sweating; dizziness; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • severe decrease in vision;
  • sudden and severe pain;
  • severe redness or other discoloration of your eyes;
  • eye pain or seeing halos around lights;
  • feeling like you might pass out;
  • chest pain; or
  • warmth or tingly feeling under your skin.

Less serious side effects may include:

  • slight changes in your vision, seeing flashes of light;
  • dry eyes;
  • redness, swelling, or itching of your eyelids;
  • seeing flashes of light;
  • headache;
  • weak or tired feeling;
  • mild itching or skin rash;
  • constipation, nausea;
  • joint pain, muscle weakness;
  • fever, chills, body aches, sore throat, flu symptoms; or
  • pain, swelling, bleeding, or itching where the medicine was injected.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about verteporfin (Visudyne)?

You should not receive this medication if you are allergic to verteporfin, or if you have porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Before receiving verteporfin, tell your doctor if you have liver or gallbladder disease, or if you are receiving radiation treatment.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Verteporfin will make your eyes and your skin more sensitive to light. After receiving verteporfin, you must protect your eyes and skin from natural sunlight and bright indoor light for at least 5 days..

Wear dark sunglasses and keep all parts of your skin covered with clothing. Sunscreen will not be effective in protecting you from UV rays during the 5-day period after you have received verteporfin.

Related Drug Centers
  • Visudyne


Related Drugs Index: