Vancomycin Hydrochloride

DRUG DESCRIPTION

Vancomycin Injection, USP in the GALAXY plastic container (PL 2040) contains vancomycin, added as Vancomycin Hydrochloride, USP. It is a tricyclic glycopeptide antibiotic derived from Amycolatopsis orientalis (formerly Nocardia orientalis). The molecular formula is C66H75Cl2N9O24 HCl and the molecular weight is 1,485.71. 500 mg of the base is equivalent to 0.34 mmol. Vancomycin hydrochloride has the following structural formula:

Vancomycin Structural Formula Illustration

Vancomycin Injection, USP in the GALAXY plastic container (PL 2040) is a frozen, isoosmotic, sterile, nonpyrogenic premixed 100 mL, 150 mL, or 200 mL solution containing 500 mg, 750 mg, or 1 g Vancomycin respectively as Vancomycin hydrochloride. Each 100 mL of solution contains approximately 5 g of Dextrose Hydrous, USP. The pH of the solution may have been adjusted with hydrochloric acid and/or sodium hydroxide. Thawed solutions have a pH in the range of 3.0 to 5.0. After thawing to room temperature, this solution is intended for intravenous use only.

This GALAXY container is fabricated from a specially designed multilayer plastic (PL 2040). Solutions are in contact with the polyethylene layer of this container and can leach out certain chemical components of the plastic in very small amounts within the expiration period. The suitability of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

What are the possible side effects of vancomycin (Lyphocin, Vancocin HCl, Vancocin HCl Pulvules)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using vancomycin and call your doctor at once if you have any of these serious side effects:

  • hearing loss, ringing in your ears;
  • urinating less than usual or not at all;
  • fever, chills, body aches, flu symptoms;
  • feeling light-headed, fainting;
  • skin rash, redness, bruising, severe...

Read All Potential Side Effects and See Pictures of Vancomycin Hydrochloride

What are the precautions when taking vancomycin hydrochloride injection (Vancomycin Hydrochloride)?

Before using vancomycin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, hearing problems, stomach/intestinal problems (e.g., inflammatory disorders of the intestines).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people...

Read All Potential Precautions of Vancomycin Hydrochloride


Vancomycin Hydrochloride Consumer (continued)

SIDE EFFECTS: If this medication is injected too fast, a condition known as "red man syndrome" may occur. Tell your doctor promptly if you have symptoms such as flushing of the upper body, dizziness, low blood pressure, or muscle pain/spasms of the chest and back.

Pain, redness, and tenderness at the injection site may occur. These effects may be reduced by injecting this medication more slowly. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: ringing in the ears, hearing problems, change in the amount of urine, easy bleeding/bruising, fever, persistent sore throat, persistent diarrhea.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using vancomycin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, hearing problems, stomach/intestinal problems (e.g., inflammatory disorders of the intestines).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at a greater risk for hearing or kidney problems while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.


Vancomycin Hydrochloride Patient Information Including Side Effects

Brand Names: Lyphocin, Vancocin HCl, Vancocin HCl Pulvules

Generic Name: vancomycin (Pronunciation: VAN koe MYE sin)

  • What is vancomycin (Vancomycin Hydrochloride)?
  • What are the possible side effects of vancomycin (Vancomycin Hydrochloride)?
  • What is the most important information I should know about vancomycin (Vancomycin Hydrochloride)?
  • What should I discuss with my healthcare provider before using vancomycin (Vancomycin Hydrochloride)?
  • How should I take vancomycin (Vancomycin Hydrochloride)?
  • What happens if I miss a dose (Vancomycin Hydrochloride)?
  • What happens if I overdose (Vancomycin Hydrochloride)?
  • What should I avoid while using vancomycin (Vancomycin Hydrochloride)?
  • What other drugs will affect vancomycin (Vancomycin Hydrochloride)?
  • Where can I get more information?

What is vancomycin (Vancomycin Hydrochloride)?

Vancomycin is an antibiotic. It fights bacteria in the body.

Vancomycin is used to treat infections of the intestines that cause colitis (inflammation of the large intestine).

Vancomycin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of vancomycin (Vancomycin Hydrochloride)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using vancomycin and call your doctor at once if you have any of these serious side effects:

  • hearing loss, ringing in your ears;
  • urinating less than usual or not at all;
  • fever, chills, body aches, flu symptoms;
  • feeling light-headed, fainting;
  • skin rash, redness, bruising, severe tingling, numbness, pain, muscle weakness; or
  • severe stomach pain, diarrhea that is watery or bloody.

Less serious side effects may include:

  • dizziness;
  • nausea;
  • back pain; or
  • muscle pain or tightness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about vancomycin (Vancomycin Hydrochloride)?

Before using vancomycin, tell your doctor if you are allergic to any drugs, or if you have kidney disease, problems with your hearing, or an intestinal disorder such as inflammatory bowel disease, Crohn's disease, or ulcerative colitis.

Vancomycin can cause temporary or permanent hearing loss. Stop using this medication and call your doctor at once if you have any hearing problems or ringing in your ears.

To be sure this medication is not causing harmful effects, your hearing will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Vancomycin will not treat a viral infection such as the common cold or flu.

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