CAPRELSA tablets for daily oral administration are available in two dosage strengths, 100 mg and 300 mg, containing 100 mg and 300 mg of vandetanib, respectively. The tablet cores contain the following inactive ingredients: Tablet core: calcium hydrogen phosphate dihydrate, microcrystalline cellulose, crospovidone, povidone, and magnesium stearate. The tablet film-coat contains the following inactive ingredients: hypromellose 2910, macrogol 300, and titanium dioxide E171.

Vandetanib is chemically described as N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1methylpiperidin-4-yl) methoxy]quinazolin-4-amine.

The structural and molecular formulas are:

CAPRELSAŽ (vandetanib) Structural Formula Illustration


Vandetanib has a molecular weight of 475.36. Vandetanib exhibits pH-dependent solubility, with increased solubility at lower pH. Vandetanib is practically insoluble in water with a value of 0.008 mg/mL at 25°C (77°F).

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