Zanosar

DRUG DESCRIPTION

Each vial of ZANOSAR contains 1 g of the active ingredient streptozocin 2 -deoxy - 2 -[[(methylnitrosoamino)carbonyl]amino] - ?(and ?) - D - glucopyranose and 220 mg citric acid anhydrous. ZANOSAR (streptozocin) is available as a sterile, pale yellow, freeze-dried preparation for intravenous administration. The pH was adjusted with sodium hydroxide. When reconstituted as directed, the pH of the solution will be between 3.5 and 4.5. Streptozocin is a synthetic antineoplastic agent that is chemically related to other nitrosoureas used in cancer chemotherapy. Streptozocin is an ivory-colored crystalline powder with a molecular weight of 265.2. It is very soluble in water or physiological saline and is soluble in alcohol. The structural formula is represented below:

Zanosar® (streptozocin) Structural Formula Illustration

What are the possible side effects of streptozocin (Zanosar)?

If you experience any of the following serious side effects from streptozocin, contact your doctor immediately or seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • kidney damage (little or no urine production, blood in the urine);
  • liver problems (changes in blood test results, abdominal pain, yellowing of the skin or eyes, decreased appetite, nausea);
  • decreased bone marrow function and blood...

Read All Potential Side Effects and See Pictures of Zanosar »

What are the precautions when taking streptozocin (Zanosar)?

Consult your...

Read All Potential Precautions of Zanosar »


Zanosar Consumer (continued)

SIDE EFFECTS: Consult your pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Consult your pharmacist.


Zanosar Patient Information Including Side Effects

Brand Names: Zanosar

Generic Name: streptozocin (Pronunciation: STREP toe zoe sin)

  • What is streptozocin (Zanosar)?
  • What are the possible side effects of streptozocin (Zanosar)?
  • What is the most important information I should know about streptozocin (Zanosar)?
  • What should I discuss with my healthcare provider before using streptozocin (Zanosar)?
  • How should I use streptozocin (Zanosar)?
  • What happens if I miss a dose (Zanosar)?
  • What happens if I overdose (Zanosar)?
  • What should I avoid while using streptozocin (Zanosar)?
  • What other drugs will affect streptozocin (Zanosar)?
  • Where can I get more information?

What is streptozocin (Zanosar)?

Streptozocin is an antineoplastic medication. Streptozocin interferes with the growth of cancer cells and slows their growth and spread in the body.

Streptozocin is used to treat cancer of the pancreas.

Streptozocin may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of streptozocin (Zanosar)?

If you experience any of the following serious side effects from streptozocin, contact your doctor immediately or seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • kidney damage (little or no urine production, blood in the urine);
  • liver problems (changes in blood test results, abdominal pain, yellowing of the skin or eyes, decreased appetite, nausea);
  • decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection); or
  • severe nausea, vomiting, loss of appetite, or diarrhea.

In some cases, secondary cancers have been reported to occur during and following treatment with streptozocin. Talk to your doctor about the risks and benefits of this medication.

Other, less serious side effects may be more likely to occur. Continue taking streptozocin and talk to your doctor if you experience:

  • mild nausea, vomiting, loss of appetite, or diarrhea;
  • drowsiness;
  • confusion;
  • depression; or
  • swelling, redness, burning, or tenderness at the injection site.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about streptozocin (Zanosar)?

Streptozocin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of streptozocin including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); kidney damage (little or no urine production, blood in the urine); liver problems (changes in blood test results, abdominal pain, yellowing of the skin or eyes, decreased appetite, nausea); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection); severe nausea, vomiting, and diarrhea; secondary cancers; and others. Talk to your doctor about the possible side effects from treatment with streptozocin.

Treatment with streptozocin may cause drowsiness or confusion. Use caution when driving, operating machinery, or performing other hazardous activities if drowsiness or confusion occurs.

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