Zyloprim

DRUG DESCRIPTION

ZYLOPRIM (allopurinol) has the following structural formula:

ZYLOPRIM (allopurinol) structural formula illustration

ZYLOPRIM (allopurinol) is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg allopurinol and the inactive ingredients lactose, magnesium stearate, potato starch, and povidone. Each scored peach tablet contains 300 mg allopurinol and the inactive ingredients corn starch, FD&C Yellow No. 6 Lake, lactose, magnesium stearate, and povidone. Its solubility in water at 37C is 80.0 mg/dL and is greater in an alkaline solution.

What are the possible side effects of allopurinol (Zyloprim)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using allopurinol and call your doctor at once if you have any of these serious side effects:

  • the first sign of any skin rash, no matter how mild;
  • pain or bleeding when you urinate;
  • urinating less than usual or not at all;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • ...

Read All Potential Side Effects and See Pictures of Zyloprim

What are the precautions when taking allopurinol (Zyloprim)?

Before taking allopurinol, tell your doctor or pharmacist if you are allergic to it; or if you have had a severe reaction to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, high blood pressure (hypertension), unusual diets (e.g., fasting).

This drug may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Alcohol may decrease the effectiveness of this drug. Limit alcoholic beverages.

Kidney...

Read All Potential Precautions of Zyloprim


Zyloprim Consumer (continued)

SIDE EFFECTS: Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: numbness/tingling of arms/legs, easy bleeding/bruising, signs of infection (e.g., fever, persistent sore throat), unusual tiredness, painful/bloody urination, change in the amount of urine, yellowing eyes/skin, severe stomach/abdominal pain, persistent nausea/vomiting, dark urine, unusual weight loss, eye pain, vision changes.

A very serious (possibly fatal) allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking allopurinol, tell your doctor or pharmacist if you are allergic to it; or if you have had a severe reaction to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, high blood pressure (hypertension), unusual diets (e.g., fasting).

This drug may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Alcohol may decrease the effectiveness of this drug. Limit alcoholic beverages.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be at greater risk for side effects while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Allopurinol passes into breast milk. Consult your doctor before breast-feeding.


Zyloprim Patient Information Including Side Effects

Brand Names: Zyloprim

Generic Name: allopurinol (Pronunciation: al oh PURE i nole)

  • What is allopurinol (Zyloprim)?
  • What are the possible side effects of allopurinol (Zyloprim)?
  • What is the most important information I should know about allopurinol (Zyloprim)?
  • What should I discuss with my healthcare provider before taking allopurinol (Zyloprim)?
  • How should I take allopurinol (Zyloprim)?
  • What happens if I miss a dose (Zyloprim)?
  • What happens if I overdose (Zyloprim)?
  • What should I avoid while taking allopurinol (Zyloprim)?
  • What other drugs will affect allopurinol (Zyloprim)?
  • Where can I get more information?

What is allopurinol (Zyloprim)?

Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones.

Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.

Allopurinol may also be used for other purposes not listed in this medication guide.

What are the possible side effects of allopurinol (Zyloprim)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using allopurinol and call your doctor at once if you have any of these serious side effects:

  • the first sign of any skin rash, no matter how mild;
  • pain or bleeding when you urinate;
  • urinating less than usual or not at all;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • bruising, severe tingling, numbness, pain, muscle weakness;
  • easy bruising or bleeding, unusual weakness;
  • fever, chills, body aches, flu symptoms;
  • jaundice (yellowing of the skin or eyes); or
  • seizure (convulsions).

Less serious side effects may include:

  • nausea, vomiting, diarrhea;
  • dizziness or drowsiness;
  • increased sweating; or
  • joint pain.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about allopurinol (Zyloprim)?

Do not use this medication if you have ever had a serious allergic reaction to allopurinol. Stop taking the medicine and call your doctor at once if you have any signs of skin rash, no matter how mild.

Take each dose with a full glass of water. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise.

Allopurinol can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

Avoid drinking alcohol. It can make your condition worse.

Allopurinol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

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